Auto-craft is your best friend
Don't forget you have Seared Heater and Melter in Tinkers' Complement
There must have a blood moon every 30 days
Use F7 to see the light levels on the ground
Use F9 to see the chunk borders
Grue will spawn when the light levels is lower than 6
Get cobblestone as fast as possible in first day
Mekanism cables tend to cause lag, be careful not to overuse them
The sound much more realistic in this Modpack